Biological Database platform

State Key Laboratory of Silkworm Genome Biology, Southwest University
College of Computer and Information Science, Southwest University
College of Animal Science and Technology, Southwest University
College of Agronomy and Biotechnology, Southwest University

Dr. Tian Li - CN

李田, 博士, 副研究员, 硕士生导师
西南大学家蚕基因组生物学国家重点实验室
西南大学蚕学与系统生物学研究所
Email: lit{at}swu.edu.cn
电话: +86-23-68251088
传真: +86-23-68251128
ORCID iD iconorcid.org/0000-0003-4362-0130

专业领域: 微生物学, 生物化学与分子生物学, 基因组学, 生物信息学
简历:
  • 2014 - ,西南大学家蚕基因组生物学国家重点实验室,副研究员,硕士生导师;
  • 2014 - 2015,美国加州大学圣地亚哥分校访问学者;
  • 2009 - 2014,西南大学蚕学与系统生物学研究所,讲师;
  • 2005 - 2009,西南大学,博士,生物化学与分子生物学专业;
  • 2003 - 2005,西南大学,硕士,微生物学专业;
  • 2001 - 2003,西南农业大学,本科,计算机科学与技术专业;
  • 1999 - 2003,西南农业大学,本科,动物医学专业。
招收研究生专业与方向:
  • 071005 微生物学
    • 方向: 微生物基因功能与应用
  • 071010 生物化学与分子生物学
    • 方向: 基因组与生物信息学
主要科研领域与方向:

主要以人畜共患和昆虫的微孢子虫病原及其宿主(昆虫与哺乳动物)为材料,从事基因组与生物信息学、微生物病原侵染机理与宿主应答机理研究。具体主要开展基因组、转录组和蛋白质组测序分析,解析病原进化与适应机制、病原侵染与宿主应答机理,研发生物信息学分析程序、平台和生物数据库等。具体为:

  • 病原与宿主相互作用的分子机理研究
    • 病原如何侵染和调控宿主?
    • 宿主如何应答病原侵染?
  • 基因组学与生物信息学
主要科学成就:
  • 参加了家蚕和桑树基因组框架图的绘制工作,完成了多个微孢子虫基因组图谱的绘制;先后主持国家自然科学基金青年基金和面上项目、重庆市自然科学基金、西南大学校级项目等多项课题,参加国家“973”、“863”、自然科学基金重点项目等多个项目;在Nucleic Acids Research、BMC Genomics、Database等国内外期刊发表研究论文40余篇,参编专著和译著各1部;搭建了生物基因组数据库平台(BioDB),构建了家蚕病原数据库(SilkPathDB)、桑树基因组数据库(MorusDB)、代表性物种qRT-PCR引物数据库(qPrimerDB)和多杀性巴氏杆菌基因组数据库(PamulDB)等多个数据库。参加完成的“家蚕基因组框架图”分别获得教育部2005年度中国高等学校十大科技进展、重庆市2005年度自然科学一等奖、日本蚕学会年度贡献奖、重庆市教育委员会“十五”重庆高校十大科技进展项目;参加完成的“家蚕微孢子虫侵染与宿主应答的分子基础”研究获得2017年度教育部高等学校科学研究优秀成果奖自然科学二等奖。
主持科研项目:
  • 国家自然科学基金面上项目 (No. 31772678),62万元, 2018 – 2021;
  • 国家自然科学基金面上项目 (No. 31472151),80万元,2015 – 2018;
  • 教育部中央高校基本业务费创新团队项目 (No. XDJK2015A010),50万元, 2015 – 2017;
  • 国家自然科学基金青年基金项目 (No. 31001036) ,20万元,2010 – 2013;
  • 重庆市自然科学基金一般项目 (No. CSTC, 2010BB1139),3万元, 2010 – 2013;
  • 教育部中央高校基本业务费一般项目(No. XDJK2009C148),5万元,2010 – 2012。
代表性论文/论著:
  1. Huang Y, Zheng S, Mei X, Yu B, Sun B, Li B, Wei J, Chen J, Li T, Pan G, Zhou Z, Li C. A secretory hexokinase plays an active role in the proliferation of Nosema bombycis. PeerJ, 2018, 6:e5658. doi: 10.7717/peerj.5658. eCollection 2018. [PubMed]
  2. Xu WF, Ren HS, Ou T, Lei T, Wei JH, Huang CS, Li T, Strobel G, Zhou ZY, Xie J. Genomic and Functional Characterization of the Endophytic Bacillus subtilis 7PJ-16 Strain, a Potential Biocontrol Agent of Mulberry Fruit Sclerotiniose. Microb Ecol. 2018, 3. doi: 10.1007/s00248-018-1247-4. [PubMed]
  3. Xian-Zhi Meng, Bo Luo, Xiang-You Tanga, Qiang He, Ting-Rong Xiong, Zhuo-Ya Fang, Guoqing Pan, Tian Li*, Ze-Yang Zhou*. Pathological analysis of silkworm infected by two microsporidia Nosema bombycis CQ1 and Vairimorpha necatrix BM. J Invertebr Pathol. 2017, pii: S0022-2011(17)30302-6. doi: 10.1016/j.jip.2017.12.005. [PubMed]
  4. Kun Lu, Tian Li, Jian He, Wei Chang, Rui Zhang, Miao Liu, Mengna Yu, Yonghai Fan, Jinqi Ma, Wei Sun, Cunmin Qu, Liezhao Liu, Nannan Li, Ying Liang, Rui Wang, Wei Qian, Zhanglin Tang, Xinfu Xu, Bo Lei, Kai Zhang, Jiana Li. qPrimerDB: a thermodynamics-based gene-specific qPCR primer database for 147 organisms. Nucleic Acids Research, 2017, gkx725. [PubMed] [PDF]. (Authors contributed equally to this paper.)
  5. Tian Li, Guo-Qing Pan, Charles R. Vossbrinck, Jin-Shan Xu, Chun-Feng Li, Jie Chen, Meng-Xian Long, Ming Yang, Xiao-Fei Xu, Chen Xu, Bettina A. Debrunner-Vossbrinck, Ze-Yang Zhou. SilkPathDB: a comprehensive resource for the study of silkworm pathogens. Database. 2017(1): bax001. [PubMed] [PDF]
  6. Ying Wang, Huixia Geng, Xiaoqun Dang, Heng Xiang, Tian Li, Guoqing Pan, Zeyang Zhou. Comparative Analysis of the Proteins with Tandem Repeats from 8 Microsporidia and Characterization of a Novel Endospore Wall Protein Colocalizing with Polar Tube from Nosema bombycis. J Eukaryot Microbiol. 2017, 64(5):707-715. [PubMed] [PDF]
  7. Donglin Yang, Lixia Pan, Pai Peng, Xiaoqun Dang, Chunfeng Li, Tian Li, Mengxian Long, Jie Chen, Yujiao Wu, Huihui Du, Bo Luo, Yue Song, Rui Tian, Jie Luo, Zeyang Zhou and Guoqing Pan. Interaction between SWP9 and Polar Tube Proteins of the Microsporidian Nosema bombycis and Function of SWP9 as a Scaffolding Protein Contribute to Polar Tube Tethering to the Spore Wall. Infect Immun. 2017, 85(3), pii: e00872-16. [PubMed] [PDF]
  8. ZhiHong Li, GuoQing Pan, ZhenGang Ma, Bing Han, Bin Sun, Qi Ni, Jie Chen, Tian Li, TongBao Liu, MengXian Long, ChunFeng Li, ZeYang Zhou. Comparative proteomic analysis of differentially expressed proteins in the Bombyx mori fat body during the microsporidia Nosema bombycis infection. J Invertebr Pathol. 2017, 149:36-43. doi:10.1016/j.jip.2017.06.009. [PubMed]
  9. Bing Han, Kang Zhou, Zhihong Li, Bin Sun, Qi Ni, Xianzhi Meng, Guoqing Pan, Chunfeng Li, Mengxian Long, Tian Li, Congzhao Zhou, Weifang Li, Zeyang Zhou. Characterization of the First Fungal Glycosyl Hydrolase Family 19 Chitinase (NbchiA) from Nosema bombycis (Nb). J Eukaryot Microbiol. 2016, 63(1):37-45. doi: 10.1111/jeu.12246. [PubMed]
  10. Huihui Du, Rendong Fang, Tingting Pan, Tian Li, Nengzhang Li, Qiang He, Rui Wu, Yuanyi Peng, and Zeyang Zhou. Comparative genomics analysis of two different virulent bovine Pasteurella multocida isolates. International Journal of Genomics. 2016(2016), accepted. http://dx.doi.org/10.1155/2016/4512493. [Link]
  11. Xu J, He Q, Ma Z, Li T, Zhang X, Debrunner-Vossbrinck BA, Zhou Z, Vossbrinck CR. The Genome of Nosema sp. Isolate YNPr: A Comparative Analysis of Genome Evolution within the Nosema/Vairimorpha Clade. PLoS One. 2016, 11(9):e0162336. doi: 10.1371/journal.pone.0162336. [PubMed]
  12. Qiwei Zeng, Hongyu Chen, Chao Zhang, Minjing Han, Tian Li, Xiwu Qi, Zhonghuai Xiang, Ningjia He. Definition of Eight Mulberry Species in the Genus Morus by Internal Transcribed Spacer-Based Phylogeny. PLoS One. 2015, 10(8):e0135411. doi: 10.1371/journal.pone.0135411. eCollection 2015. [PubMed]
  13. Ma B, Li T, Xiang Z, He N. MnTEdb, a collective resource for mulberry transposable elements. DATABASE. 2015, pii: bav004. doi: 10.1093/database/bav004. [PubMed]
  14. Liu T, Xu J, Luo B, Chen J, Li Z, Li T, Pan G, Li X, Zhou Z. Nosema sp. PM-1, a new isolate of microsporidian from infected Papilio machaon Linnaeus, based on ultrastructure and molecular identification. Acta Parasitol. 2015, 60(2): 330-336.
  15. Wang Y, Dang X, Luo B, Li C, Long M, Li T, Li Z, Pan G, Zhou Z. Characterization of a novel otubain-like protease with deubiquitination activity from Nosema bombycis (Microsporidia). Parasitol Res. 2015. [Epub ahead of print].
  16. 周泽扬,潘国庆†,李田†,许金山†.《家蚕微孢子虫基因组生物学》. 科学出版社. 2014, ISBN 978-7-03-042451-8. (†副主编).
  17. Wang Y, Dang X, Ma Q, Liu F, Pan G, Li T, Zhou Z.Characterization of a novel spore wall protein NbSWP16 with proline-rich tandem repeats from Nosema bombycis (microsporidia). Parasitology. 2014, 3:1-9. [PubMed]
  18. Tian Li, Xiwu Qi, Qiwei Zeng, Zhonghuai Xiang, Ningjia He. MorusDB: A resource for mulberry genomics and genome biology. DATABASE. 2014, bau054, doi: 10.1093/database/bau054. [PubMed]
  19. Bo Luo, Handeng Liu, Guoqing Pan, Tian Li, Zeng Li, Xiaoqun Dang, Tie Liu, Zeyang Zhou. Morphological and molecular studies of Vairimorpha necatrix BM, a new strain of the microsporidium V. necatrix (microsporidia, burenellidae) recorded in the silkworm, Bombyx mori. Exp Parasitol. 2014, pii: S0014-4894(14)00115-5. doi: 10.1016/j.exppara.2014.05.001. [PubMed]
  20. Xiang H, Zhang R, De Koeyer D, Pan G, Li T, Liu T, Zhou Z. New evidence on the relationship between Microsporidia and Fungi: a genome-wide analysis by DarkHorse software. Can J Microbiol. 2014, 14:1-12. [PubMed]
  21. Zhengang Ma, Chunfeng Li, Guoqing Pan, Zhihong Li, Bing Han, Jinshan Xu, Xiqian Lan, Jie Chen, Donglin Yang, Quanmei Chen, Qi Sang, Xiaocun Ji, Tian Li, Mengxian Long, Zeyang Zhou. 2013. Genome-wide transcriptional response of silkworm (Bombyx mori) to infection by the microsporidian Nosema bombycis. PloS ONE. 2013, 8(12): e84137. [PubMed]
  22. Chen J, Geng L, Long M, Li T, Li Z, Yang D, Ma C, Wu H, Ma Z, Li C, Pan G, Zhou Z. Identification of a novel chitin-binding spore wall protein (NbSWP12) with a BAR-2 domain from Nosema bombycis (microsporidia). Parasitology. 2013, 140(11): 1394-402.
  23. Yang D, Dang X, Tian R, Long M, Li C, Li T, Chen J, Li Z, Pan G, Zhou Z. Development of an approach to analyze the interaction between Nosema bombycis (microsporidia) deproteinated chitin spore coats and spore wall proteins. J Invertebr Pathol. 2013, pii:S0022-2011(13)00149-3.
  24. LI Zhi-Hong, MA Zhen-Gang, LI Wan-Jun, LIU Jun, HAN Bing, LI Tian, PAN Guo-Qing, LI Chun-Feng, ZHOU Ze-Yang. Analysis and Identification of the Differentially Expressed Hemolymph Proteins of Silkworm (Bombyx mori) Infected by Nosema bombycis. Science of Sericulture. 2013, 39(5): 95-101.
  25. GENG Li-Na, WU Hai-Jing, LIU Ting, TIAN Rui, LI Tian, PAN Guo-Qing, ZHOU Ze-Yang. Two-dimensional Electrophoresis Analysis of Nosema bombycis Spore Coat Proteins Prepared by Germination Method and Glas Beads Breaking Method. Science of Sericulture. 2013, 39(5): 0928-0934.
  26. LUO Jie, DENG Yuan-Hong, HUANG Wei, LI Tian, YANG Qiong, YIN Mei, PAN Guo-Qing, LI Chun-Feng, ZHOU Ze-Yang. Sequence Analysis and Subcellular Localization of a Novel Nosema bombycis Gene in Saccharomyces cerevisiae Cells. Science of Sericulture. 2013, 39(2): 0302-0309.
  27. He N, Zhang C, Qi X, Zhao S, Tao Y, Yang G, Lee TH, Wang X, Cai Q, Li D, Lu M, Liao S, Luo G, He R, Tan X, Xu Y, Li T, Zhao A, Jia L, Fu Q, Zeng Q, Gao C, Ma B, Liang J, Wang X, Shang J, Song P, Wu H, Fan L, Wang Q, Shuai Q, Zhu J, Wei C, Zhu-Salzman K, Jin D, Wang J, Liu T, Yu M, Tang C, Wang Z, Dai F, Chen J, Liu Y, Zhao S, Lin T, Zhang S, Wang J, Wang J, Yang H, Yang G, Wang J, Paterson AH, Xia Q, Ji D, Xiang Z. Draft genome sequence of the mulberry tree Morus notabilis. Nat Commun. 2013, 4:2445. doi: 10.1038/ncomms3445.
  28. LI Tian, QI Xiao-Ran, TAO Mei-Lin, LIU Xian-Lin, KANG Ding-Rong, QIN Guo-Wei, PAN Guo-Qing, ZHOU Ze-Yang. A Comparative Genomics Analysis of Secreted Proteins from Four Microsporidia. Science of Sericulture. 2013, 39(3): 0527-0536.
  29. Guoqing Pan*, Jinshan Xu*, Tian Li*, Qingyou Xia, Shao-Lun Liu, Guojie Zhang, Songgang Li, Chunfeng Li, Handeng Liu, Liu Yang, Tie Liu, Xi Zhang, Zhengli Wu, Wei Fan, Xiaoqun Dang, Heng Xiang, Meilin Tao, Yanhong Li, Junhua Hu, Zhi Li, Lipeng Lin, Jie Luo, Lina Geng, LinLing Wang, Mengxia Long, Yongji Wan, Ningjia He, Ze Zhang, Cheng Lu, Patrick J Keeling, Jun Wang, Zhonghuai Xiang and Zeyang Zhou. Comparative genomics of parasitic silkworm microsporidia reveal an association between genome expansion and host adaptation. BMC Genomics. 2013, 14: 186. (*Co-first authors).
  30. Dang X, Pan G, Li T, Lin L, Ma Q, Geng L, He Y, Zhou Z. Characterization of a subtilisin-like protease with apical localization from microsporidian Nosema bombycis. J Invertebr Pathol. 2013, 112(2): 166-174.
  31. LI Tian, LIU Xian-Lin, HAN Bing, QI Xiao-Ran, DANG Xiao-Qun, KANG Ding-Rong, PAN Guo-Qing, ZHOU Ze-Yang. A Genome-wide Prediction and Analysis on Secreted Proteins of Nosema bombycis. Science of Sericulture. 2013, 39(2): 0295-0301.
  32. MA Qiang, LI Tian, DANG Xiao-Qun, PAN Guo-Qing, XU Jing-Shan, ZHOU Ze-Yang. A Method Suitable for Extracting Membrane Protein from Nosema bombycis. Science of Sericulture. 2013, 39(2): 0319 - 0323.
  33. GENG Li-Na, WU Hai-Jing, MA Cheng, LIU Ting, DANG Xiao-Qun, QI Xiao-Ran, LI Tian, PAN Guo-Qing, ZHOU Ze-Yang. Comparative Analysis of Gene Sequences of Related Enzymes in O-mannosylation Pathway of Microsporidian. Science of Sericulture. 2012, 38(03): 158-168.
  34. Lin L, Pan G, Li T, Dang X, Deng Y, Ma C, Chen J, Luo J, Zhou Z. The protein import pore Tom40 in the Microsporidian Nosema bombycis. J Eukaryot Microbiol. 2012, 59(3):251-257.
  35. Handeng Liu, Guoqing Pan, Tian Li, Wei Huang, Bo Luo, Zeyang Zhou. Ultrastructure, chromosomal karyotype, and molecular phylogeny of a new isolate of microsporidian Vairimorpha sp. BM (Microsporidia, Nosematidae) from Bombyx mori in China. Parasitol Res. 2012, 110(1):205-210.
  36. Zhi Li, Guoqing Pan, Tian Li, Wei Huang, Jie Chen, Lina Geng, Donglin Yang, Linling Wang, Zeyang Zhou. SWP5, A Novel Spore Wall Protein Interaction with Polar Tube in the Parasite Nosema bombycis (Microsporidia). Eukaryotic Cell. 2011, 11: 229-237.
  37. Xiang H, Pan G, Zhang R, Xu J, Li T, Li W, Zhou Z, Xiang Z. Natural selection maintains the transcribed LTR retrotransposons in Nosema bombycis. J Genet Genomics. 2010, 37: 305-314.
  38. Tian Li, Xiaoqun Dang, Jinshan Xu, Handeng Liu, Guoqing Pan, Zeyang Zhou. Mitochondrial Pyruvate Dehydrogenase E1 of Nosema bombycis - a Marker in Microsporidian Evolution. Current Zoology. 2009, 55: 423-429.
  39. LI Tian, PAN Guo-Qing, DANG Xiao-Qun, ZHOU Ze-Yang. cDNA Library Construction and EST Analysis of Bombyx mori Silk Gland Heavily Infected byNosema bombycis. Science of Sericulture. 2009, 35(2): 320-327.
  40. Xia Q, Zhou Z, Lu C, Cheng D, Dai F, Li B, Zhao P, Zha X, Cheng T, Chai C, Pan G, Xu J, Liu C, Lin Y, Qian J, Hou Y, Wu Z, Li G, Pan M, Li C, Shen Y, Lan X, Yuan L, Li T, Xu H, Yang G, et al. A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science. 2004, 306: 1937-1940.

Last update: Oct 09, 2018.